Visualization of Ras-PI3K interaction in the endosome using BiFC

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Visualization of Ras-PI3K interaction in the endosome using BiFC.

Recent studies indicate the importance of spatiotemporal regulation in the diversity and specificity of intracellular signaling. Here, we show that Ras-PI3K signaling plays an important role in the local regulation of phosphatidylinositol metabolism in the endosome through live-cell imaging by using a bimolecular fluorescence complementation technique, in which molecular interaction is indicate...

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ژورنال

عنوان ژورنال: Cellular Signalling

سال: 2009

ISSN: 0898-6568

DOI: 10.1016/j.cellsig.2009.07.004